Mechanisms of intrathymic tolerance induction to isolated rat hepatocyte allografts

Tolerance induction by intrathymic expression of P0.

Genetic deficiency or instability of myelin protein zero (P0) results in hereditary motor sensory neuropathy. In view of recent advances in gene therapy, substitution of the molecular defect may become realistic in the near future. Here we investigate the impact of genetic deficiency of P0 on selection of the autoreactive T cell repertoire in the corresponding mouse model. We show that P0 mRNA ...

Induction of Immunological Tolerance to Tissue Allografts with Antilymphocyte Serum*

At the present time successful clinical organ transplantation depends on chronic administration of immunosuppressive agents to prevent the persistent tendency of the recipient to reject the graft. Chronic immunosuppressionalthough often successful in maintaining graft function and viability-is frequently associated with numerous and often fatal complications. These associated problems include: ...

Expression of P 0 Tolerance Induction by Intrathymic

Mechanisms of Tolerance Induction.

Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important path...

Metabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes

     It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...